Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

[HTML][HTML] Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Decellularization strategies for regenerative medicine: from processing techniques to applications

A Gilpin, Y Yang - BioMed research international, 2017 - Wiley Online Library
As the gap between donors and patients in need of an organ transplant continues to widen,
research in regenerative medicine seeks to provide alternative strategies for treatment. One …

Biointerface design for vertical nanoprobes

R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Bioengineering strategies to accelerate stem cell therapeutics

CM Madl, SC Heilshorn, HM Blau - Nature, 2018 - nature.com
Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …

[HTML][HTML] Substrate curvature as a cue to guide spatiotemporal cell and tissue organization

SJP Callens, RJC Uyttendaele, LE Fratila-Apachitei… - Biomaterials, 2020 - Elsevier
Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts

CJ Walker, C Crocini, D Ramirez, AR Killaars… - Nature biomedical …, 2021 - nature.com
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

MJ Dalby, N Gadegaard, ROC Oreffo - Nature materials, 2014 - nature.com
Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

[HTML][HTML] Mechanical regulation of transcription: recent advances

K Wagh, M Ishikawa, DA Garcia, DA Stavreva… - Trends in cell …, 2021 - cell.com
Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …