The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review

F Rascio, F Spadaccino, MT Rocchetti, G Castellano… - Cancers, 2021 - mdpi.com
Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

CircRNA: a rising star in gastric cancer

R Li, J Jiang, H Shi, H Qian, X Zhang, W Xu - Cellular and Molecular Life …, 2020 - Springer
In recent years, a large number of circRNAs have been identified in mammalian cells with
high-throughput sequencing technologies and bioinformatics. The aberrant expression of …

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively …

W Ni, S Yao, Y Zhou, Y Liu, P Huang, A Zhou, J Liu… - Molecular cancer, 2019 - Springer
Background YAP activation is crucial for cancer development including colorectal cancer
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Regulation of breast cancer metastasis signaling by miRNAs

BJ Petri, CM Klinge - Cancer and metastasis reviews, 2020 - Springer
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

M Shibata, K Ham, MO Hoque - International journal of cancer, 2018 - Wiley Online Library
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer

M Hu, S Zhu, S Xiong, X Xue… - Oncology reports, 2019 - spandidos-publications.com
Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …

[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology

R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

W Kang, T Huang, Y Zhou, J Zhang, RWM Lung… - Cell death & …, 2018 - nature.com
Abstract miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC).
However, its molecular mechanism remains unclear. The aim of this study is to …

Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis

H Liu, Y Liu, Z Bian, J Zhang, R Zhang, X Chen… - Molecular cancer, 2018 - Springer
Abstract Background Circular RNAs (circRNAs) are a new type of non-coding RNAs and
their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that …