Droplet-based microfluidics

T Moragues, D Arguijo, T Beneyton, C Modavi… - Nature Reviews …, 2023 - nature.com
Droplet-based microfluidic systems generate, manipulate and control sub-microlitre droplets
enclosed within an immiscible carrier fluid. Owing to a number of remarkable features, such …

Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives

H Li, Y Xie, F Chen, H Bai, L Xiu, X Zhou… - Chemical Society …, 2023 - pubs.rsc.org
Rapid and accurate molecular diagnosis is a prerequisite for precision medicine, food
safety, and environmental monitoring. The clustered regularly interspaced short palindromic …

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial

A Sartore-Bianchi, F Pietrantonio, S Lonardi… - Nature Medicine, 2022 - nature.com
Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies are approved for the
treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC), but the emergence of …

[HTML][HTML] Review of COVID-19 testing and diagnostic methods

O Filchakova, D Dossym, A Ilyas, T Kuanysheva… - Talanta, 2022 - Elsevier
More than six billion tests for COVID-19 has been already performed in the world. The
testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and …

Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications

E Tshibangu-Kabamba, Y Yamaoka - Nature Reviews Gastroenterology …, 2021 - nature.com
Helicobacter pylori is a major human pathogen for which increasing antibiotic resistance
constitutes a serious threat to human health. Molecular mechanisms underlying this …

Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

P Song, LR Wu, YH Yan, JX Zhang, T Chu… - Nature biomedical …, 2022 - nature.com
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …

Mitochondrial DNA copy number in human disease: the more the better?

R Filograna, M Mennuni, D Alsina, NG Larsson - FEBS letters, 2021 - Wiley Online Library
Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

A starting guide to root ecology: strengthening ecological concepts and standardising root classification, sampling, processing and trait measurements

GT Freschet, L Pagès, CM Iversen, LH Comas… - New …, 2021 - Wiley Online Library
In the context of a recent massive increase in research on plant root functions and their
impact on the environment, root ecologists currently face many important challenges to keep …

Integrating genomic features for non-invasive early lung cancer detection

JJ Chabon, EG Hamilton, DM Kurtz, MS Esfahani… - Nature, 2020 - nature.com
Radiologic screening of high-risk adults reduces lung-cancer-related mortality,; however, a
small minority of eligible individuals undergo such screening in the United States,. The …

ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens

T Suo, X Liu, J Feng, M Guo, W Hu, D Guo… - Emerging microbes & …, 2020 - Taylor & Francis
Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical
detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations …