Human physiology and pathology arise from the coordinated interactions of diverse single
cells. However, analyzing single cells has been limited by the low sensitivity and throughput …

This review discusses extracellular vesicles (EVs), which are submicron-scale, anuclear,
phospholipid bilayer membrane enclosed vesicles that contain lipids, metabolites, proteins …

Trypsin is the most frequently used proteolytic enzyme in mass spectrometry-based
proteomics. Beside its good availability, it also offers some major advantages such as an …

Typically, entities such as gases, small organic molecules, and ions diffuse relatively quickly.
However, the transfer of large molecules such as proteins, nucleic acids, and synthetic …

In this work, we pioneered a combination of ultralow flow (ULF) high-efficiency ultranarrow
bore monolithic LC columns coupled to MS via a high-field asymmetric waveform ion …

The synthetic particularities for the synthesis of polymer-based monolithic materials are
summarized. In this context, monoliths prepared via thermal-, UV-or electron-beam triggered …

Rigid porous polymer monoliths are a new class of materials that emerged in the early
1990s. These monolithic materials are typically prepared using a simple molding process …

The use of enzymes for cleavage, synthesis or chemical modification represents one of the
most common processes used in biochemical and molecular biology laboratories. The …

Isolation and molecular characterization of rare cells (eg circulating tumor and stem cells)
within biological fluids and tissues has significant potential in clinical diagnostics and …

The column technologies play a crucial role in the development of new methods and
technologies for the separation of biological samples containing hundreds to thousands …