Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They
are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have …

In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

To reveal the antiangiogenic capability of cancer chemotherapy, we developed an
alternative antiangiogenic schedule for administration of cyclophosphamide. We show here …

In a parallel study, Browder et al.(9) grew cyclophosphamide-resistant tumors (Lewis lung
carcinoma and EMT-6 breast carcinoma) in immunocompetent mice to focus more …

Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated,
dividing endothelial cells. Such effects may contribute to the antitumor efficacy of …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Endothelial cells (ECs) in blood vessels under formation are stabilized by the recruitment of
pericytes, both in normal tissues and during angiogenesis in pathologic situations, including …