A revolution occurred during the last decade in the comprehension of the physiology as well
as in the physiopathology of iron metabolism. The purpose of this review is to summarize the …

The hemochromatosis gene HFE was discovered in 1996, more than a century after clinical
and pathologic manifestations of hemochromatosis were reported. Linked to the major …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

Background Iron overload syndromes encompass a wide range of hereditary and acquired
conditions. Major developments in the field of genetics and the discovery of hepcidin as a …

Iron is unique among all minerals in that humans have no regulatable excretory pathway to
eliminate excess iron after it is absorbed. Iron deficiency anemia occurs when absorbed iron …

Hereditary hemochromatosis (HH) is an autosomal recessive disorder characterized by
enhanced intestinal absorption of dietary iron. Without therapeutic intervention, iron …

Numerous clinical entities have now been identified to cause pathologic iron accumulation
in the liver. Some are well described and have a verified hereditary basis; in others the …

The clinical progression of HFE-related hereditary hemochromatosis (HH) and its
phenotypic variability has been well studied. Less is known about the natural history of non …

The 'neurodegeneration with brain iron accumulation'(NBIA) disease family entails
movement or cognitive impairment, often with psychiatric features. To understand how iron …

Hereditary hemochromatosis (HH) is a widely recognized and well‐studied condition in E
uropean populations. This is largely due to the high prevalence of the C 282 Y mutation of …