[HTML][HTML] Amyloid polymorphism: structural basis and neurobiological relevance
R Tycko - Neuron, 2015 - cell.com
Our understanding of the molecular structures of amyloid fibrils that are associated with
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
Molecular mechanism of Thioflavin-T binding to amyloid fibrils
M Biancalana, S Koide - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2010 - Elsevier
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of
amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since …
amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since …
Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
Abstract The amyloid-β1–42 (Aβ42) peptide rapidly aggregates to form oligomers, protofibils
and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's …
and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's …
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils
are associated with numerous pathologies as well as with normal cellular functions,, and …
are associated with numerous pathologies as well as with normal cellular functions,, and …
Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
J Bieschke, M Herbst, T Wiglenda, RP Friedrich… - Nature chemical …, 2012 - nature.com
Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ)
polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage …
polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage …
Exploring pathological link between antimicrobial and amyloid peptides
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …
distinct families of peptides, characterized by their unique sequences, structures, biological …
Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process
Protein aggregation can lead to major disturbances of cellular processes and is associated
with several diseases. We report kinetic and equilibrium data by ThT fluorescence and …
with several diseases. We report kinetic and equilibrium data by ThT fluorescence and …
The chemistry of Alzheimer's disease
A Rauk - Chemical Society Reviews, 2009 - pubs.rsc.org
The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …
A New Structural Model of Aβ40 Fibrils
I Bertini, L Gonnelli, C Luchinat, J Mao… - Journal of the American …, 2011 - ACS Publications
The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of
Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on …
Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on …
Molecular mechanism of thioflavin-T binding to the surface of β-rich peptide self-assemblies
A number of small organic molecules have been developed that bind to amyloid fibrils, a
subset of which also inhibit fibrillization. Among these, the benzothiol dye Thioflavin-T (ThT) …
subset of which also inhibit fibrillization. Among these, the benzothiol dye Thioflavin-T (ThT) …