Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …

The molecular mechanisms underlying the antineoplastic properties of metformin, a first-line
drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome …

Prostate cancer is an androgen-dependent disease subject to interactions between the
tumor epithelium and its microenvironment. Here, we found that epigenetic changes in …

Background Hypermethylation of the promoter of the tumor suppressor gene RASSF1A
silences its expression and has been found to be associated with advanced grade prostatic …

Genistein has protective effects against prostate cancer (PCa) but whether this protection
involves an estrogen receptor (ER) β dependent mechanism has yet to be elucidated. ER-β …

Abstract miR-17-92a cluster miRNAs are transcribed from a polycistronic transcription unit
C13orf25 that generates six mature miRNAs, miR-17, miR-18a, miR-19a, miR-19b, miR-20a …

Background: Current therapeutic strategies for advanced prostate cancer (PCa) are largely
ineffective. Because aberrant DNA methylation associated with inappropriate gene-silencing …

Prostate cancer (PCa) is a major cause of cancer-related morbidity and mortality worldwide.
Although early disease is often efficiently managed therapeutically, available options for …

DNA methylation might be the earliest somatic genome changes in prostate cancer that also
play an important role in the process of tumor invasion, growth and metastasis. In recent …