It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time …

Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD
includes coronary artery diseases such as angina, myocardial infarction, and stroke.“Lipid …

Most antibodies used in immunohistochemistry (IHC) have been developed by animal
immunization. We wanted to explore naive antibody repertoires displayed on filamentous …

Background One of the hallmarks of cancer is an altered energy metabolism, and here,
mitochondria play a central role. Previous studies have indicated that some mitochondrial …

Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic
drugs with novel mechanisms of action. However, realizing its full potential for biologics …

Breast cancer tumors are composed of heterogeneous cell populations. These populations
display a high variance in morphology, growth and metastatic propensity. They respond …

Background/Aim: Primary tumors display a great level of intra-tumor heterogeneity in breast
cancer. The current lack of prognostic and predictive biomarkers limits accurate stratification …

Immunohistochemistry is a widely used technique for research and diagnostic purposes that
relies on the recognition by antibodies of antigens expressed in tissues. However, tissue …

The selection process aims sequential enrichment of phage antibody display library in
clones that recognize the target of interest or antigen as the library undergoes successive …

Internalizing antibodies have great potential for the development of targeted therapeutics.
Antibodies that internalize via the macropinocytosis pathway are particularly promising since …