Melatonin: reducing the toxicity and increasing the efficacy of drugs

RJ Reiter, D Tan, RM Sainz, JC Mayo… - Journal of Pharmacy …, 2002 - Wiley Online Library
Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine) is a molecule with a very wide
phylogenetic distribution from plants to man. In vertebrates, melatonin was initially thought to …

Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

F Halter, AS Tarnawski, A Schmassmann, BM Peskar - Gut, 2001 - gut.bmj.com
Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two
isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract …

Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination

MT Khayyal, MA El-Ghazaly, SA Kenawy… - …, 2001 - thieme-connect.com
Extracts from the plants Iberis amara, Melissa officinalis, Matricaria recutita, Carum carvi,
Mentha× piperita, Glycyrrhtza glabra, Angelica archangelica, S-lybum marianum and …

The potential of melatonin in reducing morbidity–mortality after craniocerebral trauma

MD Maldonado, F Murillo‐Cabezas… - Journal of pineal …, 2007 - Wiley Online Library
Craniocerebral trauma (CCT) is the most frequent cause of morbidity–mortality as a result of
an accident. The probable origins and etiologies are multifactorial and include free radical …

Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing

S Levi, MJ Walport, HJF Hodgson, RA Goodlad… - The Lancet, 1990 - Elsevier
To find out whether non-steroidial anti-inflammatory drugs (NSAIDs) inhibit the proliferation
of mucosal cells that normally leads to healing of gastric ulcers a microdissection technique …

Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats

G Şener-Muratoğlu, K Paskaloğlu, S Arbak… - Digestive diseases and …, 2001 - Springer
It has been reported that both omeprazole and famotidine have a protective effect against
gastric mucosal damage induced by acetylsalicylic acid (ASA) and other nonsteroidal …

Anti‐ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl‐ethanol‐induced ulcer in rats

R Anandan, PGV Nair, S Mathew - Journal of Pharmacy and …, 2004 - Wiley Online Library
The anti‐ulcerogenic effect of chitin and chitosan against ulcer induced by HCl‐ethanol in
male Wistar rats was studied. Levels of acid output, pepsin, protein, lipid peroxides and …

'Healed'experimental gastric ulcers remain histologically and ultrastructurally abnormal

A Tarnawski, D Hollander, WJ Krause… - Journal of clinical …, 1990 - journals.lww.com
The present study was designed to assess histologic and iltrastructural features of gastric
mucosa in the areas of rossly healed ulcers (acetic acid-induced gastric ulcers) in ats. The …

Role of growth factors in gastroduodenal protection and healing of peptic ulcers

SJ Konturek - Gastroenterology Clinics of North America, 1990 - Elsevier
Proliferation and growth of gastroduodenal mucosal cells represent important elements of
mucosal defense and any alterations in the balance between cell proliferation and cell loss …

Effects of zincl-carnosine on gastric mucosal and cell damage caused by ethanol in rats: Correlation with endogenous prostaglandin E2

T Arakawa, H Satoh, A Nakamura, H Nebiki… - Digestive diseases and …, 1990 - Springer
The effects of zinc l-carnosine on ethanol-induced damage and the correlation of these
effects with endogenous prostaglandin E 2 were evaluated in rat gastric mucosa in vivo and …