Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …

Due to the high heterogeneity of breast cancers, numerous recent patents describe
improved methods of detection and classification which promise better patient prognosis …

During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …

Abstract c-Jun N-terminal kinase (JNK) plays a vital role in malignant transformation of
different cancers, and JNK is highly activated in basal-like triple-negative breast cancer …

The identification of breast cancer cell subpopulations featuring truly malignant stem cell
qualities is a challenge due to the complexity of the disease and lack of general markers. By …

Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer
progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe …

Brain metastases (BrMs) evade the immune response to develop in the brain, yet the
mechanisms of BrM immune evasion remains unclear. This study shows that brain …

Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast
cancer subtypes and no current standard therapy. Here, we performed an in-depth …

Background The precise nature of how cell type specific chromatin structures at enhancer
sites affect gene expression is largely unknown. Here we identified cell type specific …