[HTML][HTML] Non-additive genetic components contribute significantly to population-wide gene expression variation
Gene expression variation, an essential step between genotype and phenotype, is
collectively controlled by local (cis) and distant (trans) regulatory changes. Nevertheless …
collectively controlled by local (cis) and distant (trans) regulatory changes. Nevertheless …
Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells
Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs.
However, genetic information can inform both identification and treatment at an early stage …
However, genetic information can inform both identification and treatment at an early stage …
[HTML][HTML] High-throughput functional analysis of regulatory variants using a massively parallel reporter assay
Association studies describe genetic associations between noncoding variants and disease
susceptibility; however, they do not provide functional insight into the underlying molecular …
susceptibility; however, they do not provide functional insight into the underlying molecular …