Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually
exposed to mechanical signals and biochemical components generated in the blood …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Background: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance
and control blood pressure. Increased vascular resistance in hypertension has been …

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …

The formation of multiprotein complexes is a repeated theme in biology ranging from the
regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the …

The ability of vertebrates to detect and avoid damaging extremes of temperature depends on
activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes …