Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

[Frontiers in Bioscience 7, d1056-1183, May 1, 2002] 1056 T CELLS AND AGING,
JANUARY 2002 UPDATE Graham Pawelec1, Yvonne Barnett Page 1 [Frontiers in …

Adoptive transfer of antigen-specific T lymphocytes is a powerful therapy for the treatment of
opportunistic disease and some virus-associated malignancies such as Epstein-Barr virus …

Transfer of autologous tumor-specific tumor infiltrating lymphocytes (TILs) in adoptive
immunotherapy can mediate the regression of tumor in patients with metastatic melanoma …

Reports differ as to whether reconstitution of telomerase activity alone is sufficient for
immortalization of different types of human somatic cells or whether additional activities …

In the decade since the telomere hypothesis of cellular aging was proposed, the two
essential genes for human telomerase were cloned and characterized, allowing …

Capacity for cellular replication is critically important for lymphocyte function and can be
regulated by telomerase-dependent maintenance of telomere length. In contrast to most …

Following a proliferative phase of variable duration, most normal somatic cells enter a
growth arrest state known as replicative senescence. In addition to telomere shortening, a …

The maintenance of specialized nucleoprotein structures termed telomeres is essential for
chromosome stability. Without new synthesis of telomeres at chromosome ends the …