Maternal vascular adaptation to pregnancy is critically important in order to expand the
capacity for blood flow through the uteroplacental unit to meet the needs of the developing …

The etiology and pathogenesis of the pregnancy syndrome preeclampsia remain poorly
understood. There is substantial evidence to suggest that the diverse manifestations of …

Several years ago the hypothesis was advanced that alterations of endothelial function
could explain much of the pathophysiology of preeclampsia. Since that time, extensive data …

Evidence exists of an association between the presence of a “lupus” anticoagulant in
plasma, recurrent fetal loss, and repeated thromboembolic accidents, also in the absence of …

Preeclampsia is a multisystem disorder peculiar to human pregnancy. It occurs in 4–5% of
all pregnancies and remains a leading cause of maternal and neonatal mortality and …

In a 31-year-old woman with a history of recurrent arterial thrombosis, both of whose
pregnancies had resulted in intrauterine death at 23 and 24 weeks, a" lupus" anticoagulant …

Patients who develop pregnancy-induced hypertension exhibit a lesser increment in
prostacyclin biosynthesis than healthy pregnant subjects. Whether this precedes the …

We investigated prostacyclin (PGI 2) biosynthesis during pregnancy by measuring urinary
excretion of 2, 3-dinor-6-keto-prostaglandin F 1α (dinor) and 15-keto-13, 14-dihydro-2, 3 …

Preeclampsia is characterized by an imbalance between two cyclooxygenase metabolites of
arachidonic acid, thromboxane and prostacyclin, that favors thromboxane. Because of the …

Uteroplacental blood flow increases as pregnancy advances. Adequate supply of nutrients
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …