Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

P Mukherjee, MA Cinelli, S Kang… - Chemical Society …, 2014 - pubs.rsc.org
Nitric oxide (NO) is an important signaling molecule in the human body, playing a crucial
role in cell and neuronal communication, regulation of blood pressure, and in immune …

A borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water

H Hikawa, H Imamura, S Kikkawa, I Azumaya - Green Chemistry, 2018 - pubs.rsc.org
We demonstrate a greener borrowing hydrogen methodology using the π-benzylpalladium
system, which offers an efficient and environmentally friendly dehydrative N …

Nitric oxide synthases and their inhibitors: a review

A Mittal, R Kakkar - Letters in Drug Design & Discovery, 2020 - ingentaconnect.com
Nitric Oxide (NO), an important biological mediator, is involved in the regulation of the
cardiovascular, nervous and immune systems in mammals. Synthesis of NO is catalyzed by …

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma

H Huang, H Li, S Yang, G Chreifi… - Journal of medicinal …, 2014 - ACS Publications
Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and
powerful agents with therapeutic potential for the treatment of chronic neurodegenerative …

The mobility of a conserved tyrosine residue controls isoform-dependent enzyme–inhibitor interactions in nitric oxide synthases

H Li, J Jamal, S Delker, C Plaza, H Ji, Q Jing… - Biochemistry, 2014 - ACS Publications
Many pyrrolidine-based inhibitors highly selective for neuronal nitric oxide synthase (nNOS)
over endothelial NOS (eNOS) exhibit dramatically different binding modes. In some cases …

Quantum dot based fluorescent traffic light nanoprobe for specific imaging of avidin-type biotin receptor and differentiation of cancer cells

H Jin, Q Jin, Z Liang, Y Liu, X Qu, Q Sun - Analytical chemistry, 2019 - ACS Publications
Sensitive and specific visualization of cell surface biotin receptors (BRs) a class of clinically
important biomarkers, remains a challenge. In this work, a dual-emission ratiometric …

Potent and selective human neuronal nitric oxide synthase inhibition by optimization of the 2-aminopyridine-based scaffold with a pyridine linker

HY Wang, Y Qin, H Li, LJ Roman… - Journal of medicinal …, 2016 - ACS Publications
Neuronal nitric oxide synthase (nNOS) is an important therapeutic target for the treatment of
various neurodegenerative disorders. A major challenge in the design of nNOS inhibitors …

Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques

S Boumezber, K Yelekçi - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
NO, or nitric oxide, is produced by a family of enzymes called nitric oxide synthase (NOS)
from L-arginine. NO regulates many physiological functions such as smooth muscle …

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase

H Huang, H Li, P Martásek, LJ Roman… - Journal of medicinal …, 2013 - ACS Publications
Nitric oxide synthases (NOSs) comprise three closely related isoforms that catalyze the
oxidation of l-arginine to l-citrulline and the important second messenger nitric oxide (NO) …

A combination of pharmacophore modeling, molecular docking and virtual screening for iNOS inhibitors from Chinese herbs

F Liu, A Goodarzi, H Wang, J Stasiak… - Bio-Medical …, 2014 - journals.sagepub.com
Inducible Nitric Oxide Synthase (iNOS) has been involved in a variety of diseases, and thus
it is interesting to discover new iNOS inhibitors. This study was performed to identify natural …