Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Tuberculosis (TB) elimination is possible with the discovery of accurate biomarkers that
define the stages of infection. Drug-resistant TB impair the current treatment strategies and …

Tuberculosis (TB) has remained an unsolved problem and a major public health issue,
particularly in developing countries. Pakistan is one of the countries with the highest …

A well-known association between vitamin D3 and infection with Mycobacterium
tuberculosis has previously been reported, but little is known regarding the underlying …

Biomarkers for treatment response would facilitate the testing of urgently needed new anti-
tuberculous drugs. The present study investigated the profiles of 30 proinflammatory, anti …

Background Household contacts of diagnostically established tuberculosis (TB) patients are
highly susceptible to disease development. It is surmised that cytokines perhaps play a …

Tuberculosis disease continues to contribute to the mortality burden globally. Due to the
several shortcomings of the available diagnostic methods, tuberculosis disease continues to …

Objectives To characterize at high resolution DNA methylation changes of cytokines which
occur in the genome of macrophages in association with Mycobacterium tuberculosis (MTB) …

Objective: To evaluate the pattern of pro-inflammatory cytokines, anti-inflammatory cytokines
and the acute phase response (APR) as markers of the response to treatment of pulmonary …

Background Tuberculosis (TB) is associated with oxidative stress and the induction of host
anti-oxidants to counteract this response. Heme oxygenase-1 (HO-1) is a critical promoter of …