Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Viral infections and pathogenesis of glaucoma: a comprehensive review

F Ahmad, N Deshmukh, A Webel… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Glaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual
degeneration of retinal ganglion cells and their axons. While glaucoma is primarily …

Ocular disease therapeutics: design and delivery of drugs for diseases of the eye

KJ Cheng, CM Hsieh, K Nepali… - Journal of medicinal …, 2020 - ACS Publications
The ocular drug discovery field has evidenced significant advancement in the past decade.
The FDA approvals of Rhopressa, Vyzulta, and Roclatan for glaucoma, Brolucizumab for wet …

Exosome-based crosstalk in glaucoma pathogenesis: a focus on oxidative stress and neuroinflammation

L Wang, X Wei - Frontiers in Immunology, 2023 - frontiersin.org
Exosomes are membrane-bound tiny particles that are released by all live cells that contain
multiple signal molecules and extensively participate in numerous normal physical activities …

T cell-mediated autoimmunity in glaucoma neurodegeneration

L Wang, X Wei - Frontiers in Immunology, 2021 - frontiersin.org
Glaucoma as the leading neurodegenerative disease leads to blindness in 3.6 million
people aged 50 years and older worldwide. For many decades, glaucoma therapy has …

Melatonin in retinal physiology and pathology: the case of age‐related macular degeneration

J Blasiak, RJ Reiter… - Oxidative medicine and …, 2016 - Wiley Online Library
Melatonin, an indoleamine, is synthesized mainly in the pineal gland in a circadian fashion,
but it is produced in many other organs, including the retina, which seems to be especially …

Generation of a transplantable population of human iPSC-derived retinal ganglion cells

O Rabesandratana, A Chaffiol, A Mialot… - Frontiers in Cell and …, 2020 - frontiersin.org
Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell
(RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful …

Characterizing the “POAGome”: A bioinformatics-driven approach to primary open-angle glaucoma

ID Danford, LD Verkuil, DJ Choi, DW Collins… - Progress in retinal and …, 2017 - Elsevier
Primary open-angle glaucoma (POAG) is a genetically, physiologically, and phenotypically
complex neurodegenerative disorder. This study addressed the expanding collection of …

Novel therapies for glaucoma: a patent review (2013-2019)

P Guglielmi, S Carradori, C Campestre… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Glaucoma is one of the main leading causes of irreversible blindness in the
world. The treatment of this disease relies on the use of drugs able to reduce/control the …

Detection of glaucoma based on cup-to-disc ratio using fundus images

I Qureshi, MA Khan, M Sharif… - International Journal of …, 2020 - inderscienceonline.com
Glaucoma is a permanent damage of optic nerves which cause of partial or complete visual
loss. This work presents a glaucoma detection scheme by measuring CDR from fundus …