Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …

Organoids bridge the gap between 2D cell lines and in vivo studies. With their 3D
organization and cellular heterogeneity, adult stem cell-derived organoids closely resemble …

Organoids have immense potential as ex vivo disease models for drug discovery and
personalized drug screening. Dynamic changes in individual organoid morphology, number …

Primary cilia are specialized organelles that sense changes in extracellular milieu, and their
malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows …

The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …

The global burden of pulmonary disease highlights an overwhelming need in improving our
understanding of lung development, disease, and treatment. It also calls for further advances …

During the past 10 years the world has experienced enormous progress in the organoids
field. Human organoids have shown huge potential to study organ development …

Primary ciliary dyskinesia (PCD) is a rare heterogenic genetic disorder associated with
perturbed biogenesis or function of motile cilia. Motile cilia dysfunction results in diminished …

Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells
have an immotile primary cilium that mediates cell signaling, and some specialized cells …