Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early
observations revealed a non-random spatial organization of the genome with a large-scale …

Over the past decade, advances in molecular methods have strikingly improved the
resolution at which nuclear genome folding can be analyzed. This revealed a wealth of …

The three dimensional organization of genomes remains mostly unknown due to their high
degree of condensation. Biophysical studies predict that condensation promotes the …

An array of motor proteins consumes chemical energy in setting up the architectures of
chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by …

Topologically stabilized polymer conformations in melts of nonconcatenated polymer rings
and crumpled globules are considered to be a good candidate for the description of the …

The role of the spatial organization of chromatin in gene regulation is a long-standing but
still open question. Experimentally it has been shown that the genome is segmented into …

Recent studies involving the 3-dimensional conformation of chromatin have revealed the
important role it has to play in different processes within the cell. These studies have also led …

Highlights•Chromatin is a large and complex system whose interactions are to a large extent
unknown.•Many coarse-grained models exist making different assumptions on internal …

The coil–globule transition of an energy polydisperse chain, a model heteropolymer system
where the number of monomer species equals the total number of monomers, is studied by …

We investigate the eigenvalue density in ensembles of large sparse Bernoulli random
matrices. Analyzing in detail the spectral density of ensembles of linear subgraphs, we …