Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Latent tuberculosis infection: myths, models, and molecular mechanisms

NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

P Sachdeva, R Misra, AK Tyagi, Y Singh - The FEBS journal, 2010 - Wiley Online Library
One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …

Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis

JM DiChiara, LM Contreras-Martinez… - Nucleic acids …, 2010 - academic.oup.com
Tuberculosis (TB) is a major global health problem, infecting millions of people each year.
The causative agent of TB, Mycobacterium tuberculosis, is one of the world's most ancient …

Defining the Transcriptional and Post-transcriptional Landscapes of Mycobacterium smegmatis in Aerobic Growth and Hypoxia

MC Martini, Y Zhou, H Sun, SS Shell - Frontiers in microbiology, 2019 - frontiersin.org
The ability of Mycobacterium tuberculosis to infect, proliferate, and survive during long
periods in the human lungs largely depends on the rigorous control of gene expression …

Mycobacterium tuberculosis transcription machinery: ready to respond to host attacks

K Flentie, AL Garner, CL Stallings - Journal of bacteriology, 2016 - Am Soc Microbiol
Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …

Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis

R Chauhan, J Ravi, P Datta, T Chen… - Nature …, 2016 - nature.com
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets,
activate bacterial adaptive responses to noxious environments. Here we reconstruct the …

A Mycobacterium tuberculosis Sigma Factor Network Responds to Cell-Envelope Damage by the Promising Anti-Mycobacterial Thioridazine

NK Dutta, S Mehra, D Kaushal - PLoS One, 2010 - journals.plos.org
Background Novel therapeutics are urgently needed to control tuberculosis (TB).
Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively drug-resistant …

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

Á Chiner-Oms, M Berney, C Boinett… - Nature …, 2019 - nature.com
The Mycobacterium tuberculosis complex (MTBC) members display different host-
specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq …

The complex architecture of mycobacterial promoters

M Newton-Foot, NCG van Pittius - Tuberculosis, 2013 - Elsevier
The genus Mycobacterium includes a variety of species with differing phenotypic properties,
including growth rate, pathogenicity and environment-and host-specificity. Although many …