Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …
Latent tuberculosis infection: myths, models, and molecular mechanisms
NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …
The sigma factors of Mycobacterium tuberculosis: regulation of the regulators
One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …
Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis
JM DiChiara, LM Contreras-Martinez… - Nucleic acids …, 2010 - academic.oup.com
Tuberculosis (TB) is a major global health problem, infecting millions of people each year.
The causative agent of TB, Mycobacterium tuberculosis, is one of the world's most ancient …
The causative agent of TB, Mycobacterium tuberculosis, is one of the world's most ancient …
Defining the Transcriptional and Post-transcriptional Landscapes of Mycobacterium smegmatis in Aerobic Growth and Hypoxia
The ability of Mycobacterium tuberculosis to infect, proliferate, and survive during long
periods in the human lungs largely depends on the rigorous control of gene expression …
periods in the human lungs largely depends on the rigorous control of gene expression …
Mycobacterium tuberculosis transcription machinery: ready to respond to host attacks
K Flentie, AL Garner, CL Stallings - Journal of bacteriology, 2016 - Am Soc Microbiol
Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets,
activate bacterial adaptive responses to noxious environments. Here we reconstruct the …
activate bacterial adaptive responses to noxious environments. Here we reconstruct the …
A Mycobacterium tuberculosis Sigma Factor Network Responds to Cell-Envelope Damage by the Promising Anti-Mycobacterial Thioridazine
Background Novel therapeutics are urgently needed to control tuberculosis (TB).
Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively drug-resistant …
Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively drug-resistant …
Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
The Mycobacterium tuberculosis complex (MTBC) members display different host-
specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq …
specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq …
The complex architecture of mycobacterial promoters
M Newton-Foot, NCG van Pittius - Tuberculosis, 2013 - Elsevier
The genus Mycobacterium includes a variety of species with differing phenotypic properties,
including growth rate, pathogenicity and environment-and host-specificity. Although many …
including growth rate, pathogenicity and environment-and host-specificity. Although many …