Ion channels as molecular targets of glioblastoma electrotherapy

T Abed, K Ganser, F Eckert, N Stransky… - Frontiers in Cellular …, 2023 - frontiersin.org
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved
treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of …

Development of a sexual dimorphism in a central pattern generator driving a rhythmic behavior: The role of glia‐mediated potassium buffering in the pacemaker …

GKH Zupanc - Developmental Neurobiology, 2020 - Wiley Online Library
Central pattern generators play a critical role in the neural control of rhythmic behaviors. One
of their characteristic features is the ability to modulate the oscillatory output. An important …

Receptive field organization across multiple electrosensory maps. II. Computational analysis of the effects of receptive field size on prey localization

L Maler - Journal of Comparative Neurology, 2009 - Wiley Online Library
The electric fish Apteronotus leptorhynchus emits a high‐frequency electric organ discharge
(EOD) sensed by specialized electroreceptors (P‐units) distributed across the fish's skin …

Wireless electrophysiology of the brain of freely swimming goldfish

E Vinepinsky, O Donchin, R Segev - Journal of Neuroscience Methods, 2017 - Elsevier
Background Fish are a diverse group of vertebrates with very different brain structures. The
study of the neurobiology of fish can thus lead to many important insights on information …

Inhibition of SK and M channel-mediated currents by 5-HT enables parallel processing by bursts and isolated spikes

T Deemyad, L Maler… - Journal of …, 2011 - journals.physiology.org
Although serotonergic innervation of sensory brain areas is ubiquitous, its effects on sensory
information processing remain poorly understood. We investigated these effects in …

Intrinsic frequency tuning in ELL pyramidal cells varies across electrosensory maps

WH Mehaffey, L Maler… - Journal of …, 2008 - journals.physiology.org
The tuning of neuronal responsiveness to specific stimulus frequencies is an important
computation across many sensory modalities. The weakly electric fish Apteronotus …

Genes linked to species diversity in a sexually dimorphic communication signal in electric fish

GT Smith, MR Proffitt, AR Smith, DB Rusch - Journal of Comparative …, 2018 - Springer
Sexually dimorphic behaviors are often regulated by androgens and estrogens. Steroid
receptors and metabolism are control points for evolutionary changes in sexual dimorphism …

Large-scale identification of proteins involved in the development of a sexually dimorphic behavior

GKH Zupanc, I Ilieş, RF Sîrbulescu… - Journal of …, 2014 - journals.physiology.org
Sexually dimorphic behaviors develop under the influence of sex steroids, which induce
reversible changes in the underlying neural network of the brain. However, little is known …

Ionic and neuromodulatory regulation of burst discharge controls frequency tuning

WH Mehaffey, LD Ellis, R Krahe, RJ Dunn… - Journal of Physiology …, 2008 - Elsevier
Sensory neurons encode natural stimuli by changes in firing rate or by generating specific
firing patterns, such as bursts. Many neural computations rely on the fact that neurons can …

Regulation of somatic firing dynamics by backpropagating dendritic spikes

WH Mehaffey, FR Fernandez, B Doiron… - Journal of Physiology …, 2008 - Elsevier
Pyramidal cells of the apteronotid ELL have been shown to display a characteristic
mechanism of burst discharge, which has been shown to play an important role in sensory …