Mechanisms of enhancer action: the known and the unknown
A Panigrahi, BW O'Malley - Genome biology, 2021 - Springer
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
Tet2 at the interface between cancer and immunity
S Jiang - Communications biology, 2020 - nature.com
Keeping a balance between DNA methylation and demethylation balance is central for
mammalian development and cell function, particularly in the hematopoietic system. In …
mammalian development and cell function, particularly in the hematopoietic system. In …
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer
In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9
DM Sapozhnikov, M Szyf - Nature Communications, 2021 - nature.com
Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
J Charlton, EJ Jung, AL Mattei, N Bailly, J Liao… - Nature …, 2020 - nature.com
Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation
The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its
members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 …
members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 …
TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss
C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li… - Autophagy, 2022 - Taylor & Francis
Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of
postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA …
postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA …
A practical guide to the measurement and analysis of DNA methylation
BD Singer - American journal of respiratory cell and molecular …, 2019 - atsjournals.org
DNA methylation represents a fundamental epigenetic mark that is associated with
transcriptional repression during development, maintenance of homeostasis, and disease …
transcriptional repression during development, maintenance of homeostasis, and disease …