Ketone bodies: from enemy to friend and guardian angel
H Kolb, K Kempf, M Röhling, M Lenzen-Schulte… - BMC medicine, 2021 - Springer
During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
The gut metabolite indole-3 propionate promotes nerve regeneration and repair
E Serger, L Luengo-Gutierrez, JS Chadwick, G Kong… - Nature, 2022 - nature.com
The regenerative potential of mammalian peripheral nervous system neurons after injury is
critically limited by their slow axonal regenerative rate. Regenerative ability is influenced by …
critically limited by their slow axonal regenerative rate. Regenerative ability is influenced by …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the
maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome …
maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome …
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …
its influence on immunity and metabolism, caloric restriction and fasting appear to be …
Metabolism and colorectal cancer
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …
Effects of intermittent fasting on health, aging, and disease
R De Cabo, MP Mattson - New England Journal of Medicine, 2019 - Mass Medical Soc
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …
Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans
Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer
daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in …
daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in …
Intermittent and periodic fasting, longevity and disease
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …