The role of 3D genome organization in development and cell differentiation
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …
packaged inside the nucleus. This complex genome organization includes multiscale …
Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
Mediterranean diet as an antioxidant: the impact on metabolic health and overall wellbeing
KV Gantenbein, C Kanaka-Gantenbein - Nutrients, 2021 - mdpi.com
It has been established, worldwide, that non-communicable diseases such as obesity,
diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of …
diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of …
Mitochondrial reactive oxygen species (ROS) production alters sperm quality
R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
Genetics of male infertility
C Krausz, V Rosta, RS Swerdloff, C Wang - Emery and rimoin's principles …, 2022 - Elsevier
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
Epigenetic mechanisms of transmission of metabolic disease across generations
VM Sales, AC Ferguson-Smith, ME Patti - Cell metabolism, 2017 - cell.com
Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …
early life can robustly influence risk for adult disease. Moreover, environmental exposures …
Obesity, a serious etiologic factor for male subfertility in modern society
Y Liu, Z Ding - Reproduction, 2017 - rep.bioscientifica.com
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …
Paternal factors contributing to embryo quality
Purpose Advancing maternal and paternal age leads to a decrease in fertility, and hence,
many infertile couples opt for assisted reproductive technologies [ART] to achieve biological …
many infertile couples opt for assisted reproductive technologies [ART] to achieve biological …
Cultural trauma and epigenetic inheritance
The question of whether and how the effects of cultural trauma can be transmitted
intergenerationally from parents to offspring, or even to later generations, has evoked …
intergenerationally from parents to offspring, or even to later generations, has evoked …
Role of genetics and epigenetics in male infertility
S Gunes, SC Esteves - Andrologia, 2021 - Wiley Online Library
Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …