The role of 3D genome organization in development and cell differentiation

H Zheng, W Xie - Nature reviews Molecular cell biology, 2019 - nature.com
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

R Yehuda, A Lehrner - World psychiatry, 2018 - Wiley Online Library
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

Mediterranean diet as an antioxidant: the impact on metabolic health and overall wellbeing

KV Gantenbein, C Kanaka-Gantenbein - Nutrients, 2021 - mdpi.com
It has been established, worldwide, that non-communicable diseases such as obesity,
diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of …

Mitochondrial reactive oxygen species (ROS) production alters sperm quality

R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Genetics of male infertility

C Krausz, V Rosta, RS Swerdloff, C Wang - Emery and rimoin's principles …, 2022 - Elsevier
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Epigenetic mechanisms of transmission of metabolic disease across generations

VM Sales, AC Ferguson-Smith, ME Patti - Cell metabolism, 2017 - cell.com
Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …

Obesity, a serious etiologic factor for male subfertility in modern society

Y Liu, Z Ding - Reproduction, 2017 - rep.bioscientifica.com
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …

Paternal factors contributing to embryo quality

S Colaco, D Sakkas - Journal of assisted reproduction and genetics, 2018 - Springer
Purpose Advancing maternal and paternal age leads to a decrease in fertility, and hence,
many infertile couples opt for assisted reproductive technologies [ART] to achieve biological …

Cultural trauma and epigenetic inheritance

A Lehrner, R Yehuda - Development and psychopathology, 2018 - cambridge.org
The question of whether and how the effects of cultural trauma can be transmitted
intergenerationally from parents to offspring, or even to later generations, has evoked …

Role of genetics and epigenetics in male infertility

S Gunes, SC Esteves - Andrologia, 2021 - Wiley Online Library
Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …