Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

The cornea is the clear tissue at the front of the eye which enables the transmission of light
to the retina for normal vision. The surface of the cornea is composed of an epithelium which …

Stem cell (SC) division, deployment, and differentiation are processes that contribute to
corneal epithelial renewal. Until now studying the destiny of these cells in a living mammal …

A strong cohort of evidence exists that supports the localisation of corneal stem cells at the
limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling …

Chemical eye injury (CEI) is an acute emergency which can threaten sight and life. These
commonly occur at home or the workplace with the former being generally mild and the latter …

The cornea is the clear tissue at the front of the eye that transmits light to the retina at the
back of the eye. The cornea is covered by an epithelium and surrounded by a narrow band …

During morphogenesis, preserving tissue boundaries is essential for cell fate regulation.
While embryonic tissues possess high plasticity and repair ability, the questions of whether …