The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

For over 40 years, natural products have served us well in combating cancer. The main
sources of these successful compounds are microbes and plants from the terrestrial and …

Nowadays, biochemical analysis such as cell analysis, disease diagnosis and treatment,
environmental monitoring and food safety are gaining increasing attention. Optically …

Hydroxycoumarin (4HC) type anticoagulants (for example, warfarin) are known to have a
significant role in the treatment of thromboembolic diseases—a leading cause of patient …

Covering: 1990 to 2010 Heterologous biosynthesis has emerged as a viable route to access
the beneficial properties of natural products. This development primarily owes to the …

The need for new antimicrobials is indisputable. The flight from natural products in drug
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …

Tetracyclines are a class of antibiotics that exhibited potent activity against a wide range of
Gram-positive and Gram-negative bacteria, yet only five members were isolated from …

Recent efforts in genome mining of ribosomally synthesized and post-translationally
modified peptides (RiPPs) have expanded the diversity of post-translational modification …

Cyclization of aromatic polyketides from bacteria and fungi - Natural Product Reports (RSC
Publishing) DOI:10.1039/B911518H Royal Society of Chemistry View PDF VersionPrevious …

Natural tetracycline (TC) antibiotics were the first major class of therapeutics to earn the
distinction of 'broad-spectrum antibiotics' and they have been used since the 1940s against …