The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is linked with
increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative …

The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

In spite of the fact that a surgical procedure may have been performed for the appropriate
indication and in a technically perfect manner, patients are threatened by perioperative …

Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …