The calorie restriction paradigm has provided one of the most widely used and most useful
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …

Almost exactly 100 years ago Osborne and colleagues demonstrated that restricting the food
intake of a small number of female rats extended their lifespan. In the 1930s experiments on …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …

Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its
effect on the skin is poorly understood. Here, we show that CR mice display fur coat …

The complexity of aging is hard to be captured. However, apart from its tissue-specific
features, a structural and functional progressive decline of the whole organism that leads to …

The evolutionary context of why caloric restriction (CR) activates physiological mechanisms
that slow the process of aging remains unclear. The main goal of this analysis was to …

Calorie restriction (CR) delays the onset of age-related disease and extends lifespan in a
number of species. When faced with reduced energy supply animals need to lower energy …

Under calorie restriction (CR) animals need to lower energy demands. Whether this involves
a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to …

Diet restriction (DR) ameliorates obesity by regulating mitochondrial function. Cardiolipin
(CL), a mitochondrial phospholipid, is closely associated with mitochondrial function. This …

Food intake and circadian rhythms are regulated by hypothalamic neuropeptides and
circulating hormones, which could mediate the anti‐ageing effect of calorie restriction (CR) …