Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss

S Pouwels, N Sakran, Y Graham, A Leal, T Pintar… - BMC endocrine …, 2022 - Springer
Given the increasing prevalence of diabetes and obesity worldwide, the deleterious effects
of non-alcoholic fatty liver disease (NAFLD) are becoming a growing challenge for public …

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

K Kazankov, SMD Jørgensen, KL Thomsen… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …

Quasi-LD-Targeted and ONOO-Responsive Fluorescent Probe for Investigating the Interaction of Nonalcoholic Fatty Liver with Drug-Induced Liver Injury

N Wang, X Lu, J Wang, H Wang, B Zhang… - Analytical …, 2023 - ACS Publications
Hepatic lipid droplets (LDs) and peroxynitrite (ONOO–) levels are closely related to
nonalcoholic fatty liver disease (NAFLD). Additionally, some drug-induced liver injury (DILI) …

Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases

J Gutiérrez-Cuevas, A Santos… - International Journal of …, 2021 - mdpi.com
Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms

CY Lian, ZZ Zhai, ZF Li, L Wang - Chemico-biological interactions, 2020 - Elsevier
Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …

Beneficial effects of betaine: a comprehensive review

MK Arumugam, MC Paal, TM Donohue Jr, M Ganesan… - Biology, 2021 - mdpi.com
Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

Animal models of nonalcoholic fatty liver disease—a starter's guide

MA Van Herck, L Vonghia, SM Francque - Nutrients, 2017 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the
increasing incidence of obesity and diabetes in many Western countries, reaching a …

Preclinical models of non-alcoholic fatty liver disease

PK Santhekadur, DP Kumar, AJ Sanyal - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) can manifest as non-alcoholic fatty liver (NAFL) or
non-alcoholic steatohepatitis (NASH). NASH is often associated with progressive fibrosis …

It is high time physicians thought of natural products for alleviating NAFLD. Is there sufficient evidence to use them?

G Tarantino, C Balsano, SJ Santini, G Brienza… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease all over
the world due to the obesity pandemic; currently, therapeutic options for NAFLD are scarce …

[HTML][HTML] Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis

AA Widjaja, BK Singh, E Adami, S Viswanathan… - Gastroenterology, 2019 - Elsevier
Background & Aims We studied the role of interleukin 11 (IL11) signaling in the
pathogenesis of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs) …