Competitive cooperation of hemagglutinin and neuraminidase during influenza A virus entry

R Du, Q Cui, L Rong - Viruses, 2019 - mdpi.com
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic
activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA …

Packaging signal of influenza A virus

X Li, M Gu, Q Zheng, R Gao, X Liu - Virology Journal, 2021 - Springer
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA
segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) …

The influenza A virus genome packaging network—complex, flexible and yet unsolved

C Jakob, R Paul-Stansilaus, M Schwemmle… - Nucleic Acids …, 2022 - academic.oup.com
The genome of influenza A virus (IAV) consists of eight unique viral RNA segments. This
genome organization allows genetic reassortment between co-infecting IAV strains …

Apolipoprotein E mediates cell resistance to influenza virus infection

P Gao, M Ji, X Liu, X Chen, H Liu, S Li, B Jia, C Li… - Science …, 2022 - science.org
Viruses exploit host cell machinery to support their replication. Defining the cellular proteins
and processes required for a virus during infection is crucial to understanding the …

Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin

X Chen, L Si, D Liu, P Proksch, L Zhang, D Zhou… - European journal of …, 2015 - Elsevier
A class of prenylated indole diketopiperazine alkaloids including 15 new compounds
namely rubrumlines AO obtained from marine-derived fungus Eurotium rubrum, were tested …

[HTML][HTML] Revisiting influenza A virus life cycle from a perspective of genome balance

R Du, Q Cui, Z Chen, X Zhao, X Lin, L Rong - Virologica Sinica, 2023 - Elsevier
Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the
replication is well orchestrated and the delicate balance of multiple segments are …

[HTML][HTML] Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases

S Mitra, U Anand, R Sanyal, NK Jha, T Behl… - Biomedicine & …, 2022 - Elsevier
Neoechinulins are fungal and plant-derived chemicals extracted from Microsporum sp.,
Eurotium rubrum, Aspergillus sp., etc. Two analogues of neoechinulin, ie, A and B, exerted …

Selective flexible packaging pathways of the segmented genome of influenza A virus

I Haralampiev, S Prisner, M Nitzan, M Schade… - Nature …, 2020 - nature.com
The genome of influenza A viruses (IAV) is encoded in eight distinct viral ribonucleoproteins
(vRNPs) that consist of negative sense viral RNA (vRNA) covered by the IAV nucleoprotein …

Sequential disruption of SPLASH-identified vRNA–vRNA interactions challenges their role in influenza A virus genome packaging

C Jakob, GL Lovate, D Desirò, L Gießler… - Nucleic Acids …, 2023 - academic.oup.com
A fundamental step in the influenza A virus (IAV) replication cycle is the coordinated
packaging of eight distinct genomic RNA segments (ie vRNAs) into a viral particle. Although …

A conserved influenza A virus nucleoprotein code controls specific viral genome packaging

ÉA Moreira, A Weber, H Bolte, L Kolesnikova… - Nature …, 2016 - nature.com
Packaging of the eight genomic RNA segments of influenza A viruses (IAV) into viral
particles is coordinated by segment-specific packaging sequences. How the packaging …