Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

PARP inhibitors drive increased DNA damage, particularly in tumors with existing defects in
DNA repair. This damage not only promotes immune priming through a range of molecular …

Chemotherapeutics target rapidly dividing cancer cells by directly or indirectly inducing DNA
damage. Upon recognizing DNA damage, cells initiate a variety of signaling pathways …

Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies
mainly on its ability to cause lethal damage to the DNA of cancer cells. However, some …

DNA damage repair deficiency leads to the increased risk of genome instability and
oncogenic transformation. In the meanwhile, this deficiency could be exploited for cancer …

Transcriptome analysis reveals a strong positive correlation between human Schlafen family
member 11 (SLFN11) expression and the sensitivity of tumor cells to DNA-damaging agents …

Gastric cancer (GC) is highly heterogeneous in the stromal and immune microenvironment,
genome instability (GI), and oncogenic signatures. However, a classification of GC by …

The capacity to repair different types of DNA damage varies among individuals, making
them more or less susceptible to the detrimental health consequences of damage …

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA
damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the …