Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

A Singh Grewal, S Bhardwaj, D Pandita… - Mini reviews in …, 2016 - ingentaconnect.com
Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Aldose reductase inhibitors of plant origin

C Veeresham, A Rama Rao, K Asres - Phytotherapy Research, 2014 - Wiley Online Library
Diabetic complications are attributed to hyperglycaemic condition which is in turn associated
with the polyol pathway and advanced glycation end products. Aldose reductase (AR) is the …

Medicinal plants and natural products used in cataract management

D Tewari, O Samoilă, D Gocan, A Mocan… - Frontiers in …, 2019 - frontiersin.org
Cataract is the leading reason of blindness worldwide and is defined by the presence of any
lens opacities or loss of transparency. The most common symptoms of cataract are impaired …

Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review

AI Dănilă, LA Ghenciu, ER Stoicescu, SL Bolintineanu… - Biomedicines, 2024 - mdpi.com
The escalating global prevalence of diabetes mellitus (DM) over the past two decades has
led to a persistent high incidence of diabetic retinopathy (DR), necessitating screening for …

Effect of resveratrol, a dietary-derived polyphenol, on the oxidative stress and polyol pathway in the lens of rats with streptozotocin-induced diabetes

L Sedlak, W Wojnar, M Zych… - Nutrients, 2018 - mdpi.com
Resveratrol is found in grapes, apples, blueberries, mulberries, peanuts, pistachios, plums
and red wine. Resveratrol has been shown to possess antioxidative activity and a variety of …

Green synthesis, spectroscopic investigation, quantum chemical and molecular docking studies of 3-methylisoxazolo [4, 5-b] pyridine

E Dhanalakshmi, P Rajesh, S Suresh… - Journal of Molecular …, 2024 - Elsevier
The present work, synthesized molecular compound of MIP from carbinol extract of
Hybanthus Enneaspermus by green synthesis method. The GC–MS analysis method has …

Phytochemical standardization of Aloe vera extract by HPTLC techniques

DK Patel, K Patel, SP Dhanabal - Journal of Acute Disease, 2012 - Elsevier
Objective To examine the phytochemical parameters of Aloe vera (A. vera) L. which can be
used as a tool for its standardization. Methods The phytochemical analysis, solubility test …

[HTML][HTML] Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats

K Szałabska-Rąpała, M Zych, W Borymska… - Biomedicine & …, 2024 - Elsevier
In diabetes hyperglycemia, excessive production of free radicals and present oxidative
stress lead to many complications in the body, including male reproductive system …

Aldose reductase inhibitory and antiglycation properties of phytoconstituents of Cichorium intybus: Potential therapeutic role in diabetic retinopathy

S Ahmad, MFA Ahmad, S Alouffi, S Khan… - International Journal of …, 2024 - Elsevier
Diabetic vascular complication including diabetic retinopathy is a major morbidity in Saudia
Arabia. The polyol pathway aka aldose reductase (AR) pathway has gained significant …

Daidzein ameliorates diabetic retinopathy in experimental animals

AP Laddha, YA Kulkarni - Life Sciences, 2021 - Elsevier
Aim The present study was designed to check the effect of daidzein in the management of
diabetic retinopathy. Main methods Streptozotocin at dose 55 mg/kg was used for inducing …