Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …

Dysmorphogenesis of the cardiac outflow tract (OFT) causes many congenital heart defects,
including those associated with DiGeorge syndrome. Genetic manipulation in the mouse …

The identification of new signaling pathways critical for cardiac morphogenesis will
contribute to our understanding of congenital heart disease (CHD), which remains a leading …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

The T-box gene family encodes a large family of transcription factors with more than 20
members identified in humans so far, and homologues in many other organisms. A number …

Retinoic acid (RA), the active derivative of vitamin A, has been implicated in various steps of
cardiovascular development. The retinaldehyde dehydrogenase 2 (RALDH2) enzyme …

Its high population prevalence, estimated to be as common as 1: 2000 has sparked a large
amount of research, as has the model the syndrome serves for identifying the causes of …

The secondary heart field is a conserved developmental domain in avian and mammalian
embryos that contributes myocardium and smooth muscle to the definitive cardiac arterial …

Summary 22q11 deletion (del22q11) syndrome is characterized genetically by
heterozygous deletions within chromosome 22q11 and clinically by a constellation of …