Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy,
hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a …

Non-alcoholic fatty liver disease (NAFLD) constitutes a spectrum of disease states
characterized by hepatic steatosis and is closely associated to obesity and the metabolic …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Decreased adipose tissue regulatory T cells contribute to insulin resistance in obese mice,
however, little is known about the mechanisms regulating adipose tissue regulatory T cells …

Obesity and its comorbidities are closely related to the inflammatory environment created by
expanded adipose tissue. Several mechanisms trigger inflammation in adipose tissue …

Tregs can adopt a catabolic metabolic program with increased capacity for fatty acid
oxidation–fueled oxidative phosphorylation (OXPHOS). It is unclear why this form of …

Abstract Purpose of the Review Obesity and type 2 diabetes (T2D) are considered chronic
inflammatory diseases. While early publications have reported the implication of innate …

Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also
serves as an important endocrine organ that impacts organismal metabolism. Chronic, low …

Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM)
encompasses inflammation and autoimmune aspects is increasingly recognized. In the state …

Chronic low-grade inflammation is a central component in the pathogenesis of obesity-
related expansion of adipose tissue and complications in other metabolic tissues. Five …