[HTML][HTML] Characteristics of SARS-CoV-2 and COVID-19

B Hu, H Guo, P Zhou, ZL Shi - Nature Reviews Microbiology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute …

[HTML][HTML] Lifting the mask on neurological manifestations of COVID-19

A Pezzini, A Padovani - Nature Reviews Neurology, 2020 - nature.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it
is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to …

[HTML][HTML] Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

A Narayanan, M Narwal, SA Majowicz… - Communications …, 2022 - nature.com
SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug
development. In this study, we present an antiviral screening strategy involving a novel in …

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

I Astuti - Diabetes & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
Background and aim As a result of its rapid spread in various countries around the world, on
March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 …

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

TJ Guzik, SA Mohiddin, A Dimarco, V Patel… - Cardiovascular …, 2020 - academic.oup.com
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents
the greatest medical challenge in decades. We provide a comprehensive review of the …

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

D Bestle, MR Heindl, H Limburg… - Life science …, 2020 - life-science-alliance.org
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …

[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

H Zhang, JM Penninger, Y Li, N Zhong… - Intensive care medicine, 2020 - Springer
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) …

Candidate drugs against SARS-CoV-2 and COVID-19

DL McKee, A Sternberg, U Stange, S Laufer… - Pharmacological …, 2020 - Elsevier
Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global
health for the future. Because a vaccine against the virus will not be available in the near …

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

G Li, E De Clercq - Nature reviews Drug discovery, 2020 - nature.com
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …