The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Lactic acid production has been regarded as a mechanism by which malignant cells escape
immunosurveillance. Recent technological advances in mass spectrometry and the use of …

Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

Imbalance of macrophage polarization characterized by an increase in the percentage of
pro‐inflammatory M1 macrophages and a decrease in anti‐inflammatory M2 macrophages …

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Metabolites generated from cellular and tissue metabolism have been rediscovered in
recent years as signalling molecules. They may act as cofactor of enzymes or be linked to …

Neurotransmitters have been well documented to determine immune cell fates; however,
whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Macrophages are highly plastic in different tissues and can differentiate into functional
subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of …