Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …

Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …

Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …

Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …