Leydig cells in patients with non-obstructive azoospermia: do they really proliferate?

D Hauptman, MH Perić, T Marić, AK Bojanac, N Sinčić… - Life, 2021 - mdpi.com
Background: Non-obstructive azoospermia (NOA) is a form of male infertility caused by
disorders of the testicular parenchyma and impaired spermatogenesis. This study aimed to …

A large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity

S Verhelst, B Van Puyvelde, S Willems, S Daled… - Scientific reports, 2022 - nature.com
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds
on protein expression through heritable, non-genetic mechanisms, such as histone post …

Teratoma growth retardation by HDACi treatment of the tumor embryonal source

J Krasic, L Skara, M Ulamec, A Katusic Bojanac… - Cancers, 2020 - mdpi.com
Simple Summary Testicular germ cell tumors are the most common neoplasms in young
male populations, with a rising incidence. Among them, teratomas may often be very …

Valproate targets mammalian gastrulation impairing neural tissue differentiation and development of the placental source in vitro

A Katušić-Bojanac, M Plazibat… - International journal of …, 2022 - mdpi.com
The teratogenic activity of valproate (VPA), an antiepileptic and an inhibitor of histone
deacetylase (HDACi), is dose-dependent in humans. Previous results showed that VPA …

Large scale toxicoepigenetics on histones: a mass spectrometry-based screening assay applied to developmental toxicity

S Verhelst, B Van Puyvelde, S Willems, S Daled… - 2021 - researchsquare.com
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds
on protein expression through heritable, non-genetic mechanisms, such as histone post …

Utjecaj valproata na postimplantacijski zametak u ex vivo modelu razvoja štakora

M Plazibat - 2020 - repozitorij.mef.unizg.hr
Valproat (VPA), antiepileptički lijek/teratogen je također epigenetički inhibitor histonske
deacetilaze (HDACi). Cilj disertacije bio je istražiti aktivnost VPA na gastrulaciju sisavaca u …

Hipertrofija i hiperplazija Leydigovih stanica u muškaraca s neopstruktivnom azoospermijom

D Hauptman - 2021 - repozitorij.mef.unizg.hr
Neopstruktivna azoospermija (NOA) je oblik muške neplodnosti uzrokovan poremećajima
parenhima sjemenika i oštećenjem spermatogeneze. Biopsije sjemenika muškaraca s NOA …

[PDF][PDF] Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal Source

S Dabelic, F Bulic-Jakus, D Jezek, N Sincic - researchgate.net
Among testicular germ cell tumors, teratomas may often be very aggressive and therapy-
resistant. Our aim was to investigate the impact of histone deacetylase inhibitors (HDACi) on …

[引用][C] The wonderful world of histones and stem cells: a fairy tale written by mass spectrometry

S Verhelst - 2023 - biblio.ugent.be
In reproductive and developmental toxicity assessment, there is a considerable need for
both alternative assays and additional targets [314–316]. This is because i) it is essentially …