As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …

Vascular smooth muscle cells can perform both contractile and synthetic functions, which
are associated with and characterised by changes in morphology, proliferation and …

Background—Phenotypic switching of vascular smooth muscle cells from a contractile to a
synthetic state is implicated in diverse vascular pathologies, including atherogenesis …

Tissue fibrosis is a major cause of morbidity, and idiopathic pulmonary fibrosis (IPF) is a
terminal illness characterized by unremitting matrix deposition in the lung. The mechanisms …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

Hyaluronan (HA) is a versatile molecular tool with considerable potential for tissue
engineering applications. The inclusion of HA has created biocompatible biomaterials and …

Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In
our study, we aimed to probe atherosclerosis-associated inflammation by using hyaluronan …

The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as
well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of …