Chronic inflammation is a key driver for colitis-associated colorectal cancer. 5-
hydroxytryptamine (5-HT), a neurotransmitter, has been reported to promote inflammation in …

In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …

The 5-hydroxytryptamine-3 receptor (5-HT3R), a subtype of serotonin receptor, is a ligand-
gated ion channel crucial in mediating fast synaptic transmission in the central and …

Background Ulcerative colitis (UC) is an inflammatory bowel disease that causes
inflammation and ulcers in the digestive tract. Approximately 3 million US adults suffer from …

Stress-induced abnormalities in gut monoamine levels (eg, serotonin, dopamine,
norepinephrine) have been linked to gastrointestinal (GI) dysfunction, as well as the …

The enteric nervous system (ENS) interacts bidirectionally with the local immune system,
responding to inflammation within the gastrointestinal (GI) tract. In a previous study using the …

Мигрень является сложным и распространенным заболеванием, в патогенез которого
вовлечены сосудистые, тригеминальные и нейротропные механизмы, в их инициации …