Retinoids comprise a group of compounds each composed of three basic parts: a
trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side …

Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

Using the Nephrotic Syndrome Study Network Consortium data set and other publicly
available transcriptomic data sets, we identified retinoic acid receptor responder protein 1 …

Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) plays a critical role in the
regulation of blood pressure and fluid volume homeostasis. Mice lacking functional Npr1 …

Retinoid acid (RA) is synthesized mainly in the liver and has multiple functions in
development, cell differentiation and proliferation, and regulation of inflammation. RA has …

While the uses of retinoids for cancer treatment continue to evolve, this review focuses on
other therapeutic areas in which retinoids [retinol (vitamin A), all-trans retinoic acid (RA), and …

The present study aims to formulate all-trans retinoic acid (ATRA) loaded chitosan/
tripolyphosphate lipid hybrid nanoparticles (CTLHNs) for enhancing its solubility and oral …

Podocyte injury resulting from a loss of differentiation is the hallmark of many glomerular
diseases. We previously showed that retinoic acid (RA) induces podocyte differentiation via …

Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function and
affects~ 13.4% of the global population. Progressive tubulointerstitial fibrosis, driven in part …

A low nephron number has been advocated to explain the association between intrauterine
growth restriction (IUGR) and hypertension in later life. IUGR not only leads to a low birth …