Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …

Developing functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

The worldwide paucity of transplantable organs for patients is a devastating problem. While
different approaches have been conceived to address this donor organ shortage, one …

Introduction Pluripotent stem cells can be generated from somatic cells by the Yamanaka
factors Oct4, Sox2, Klf4 and c-Myc. Methods Mouse embryonic fibroblasts (MEFs) were …

Background Ectopic expression of a defined set of transcription factors allows the
reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in …

Human pluripotent stem cells (hPSCs) exist in at least two distinct states in mammals: naïve
pluripotency that represents several molecular characteristics in pre-implantation epiblast …

For nearly three decades, more than 80 embryonic stem cell lines and more than 100
induced pluripotent stem cell lines have been derived from New World monkeys, Old World …