The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Constitutive modeling is a cornerstone for stress analysis of mechanical behaviors of
biological soft tissues. Recently, it has been shown that machine learning (ML) techniques …

Inverse modeling approaches in cardiovascular medicine are a collection of methodologies
that can provide non-invasive patient-specific estimations of tissue properties, mechanical …

Soft materials play an integral part in many aspects of modern life including autonomy,
sustainability, and human health, and their accurate modeling is critical to understand their …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

BACKGROUND: Transmural failure of the aorta is responsible for substantial morbidity and
mortality; it occurs when mechanical stress exceeds strength. The aortic root and ascending …

The evolving microstructure and mechanical properties that promote homeostasis in the
aorta are fundamental to age-specific adaptations and disease progression. We combine ex …

Findings from basic science and clinical studies agree that arterial stiffness is fundamental to
both the mechanobiology and the biomechanics that dictate vascular health and disease …

Many genetic mutations adversely affect the structure and function of load-bearing soft
tissues, with clinical sequelae often responsible for disability or death. Parallel advances in …

Constitutive laws that describe the mechanical responses of cardiac tissue under loading
hold the key to accurately model the biomechanical behaviour of the heart. There have been …