Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

Aim Over the last decades, the shift in age distribution towards older ages and the
progressive ageing which has occurred in most populations have been paralleled by a …

Obesity is a chronic disease resulting from multifactorial causes mainly related to lifestyle
(sedentary lifestyle, inadequate eating habits) and to other conditions such as genetic …

Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age‐
related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 …

ANKRD26 is a highly conserved gene located on chromosome 10p12. 1 which has shown
to play a role in normal megakaryocyte differentiation. ANKRD26-related thrombocytopenia …

For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has
continued to rise on a global level. The risk contributing to this pandemic implicates both …

Polycyclic aromatic hydrocarbons (PAHs) refer to a ubiquitous group of anthropogenic air
pollutants that are generated through incomplete carbon combustion. Although the …

During gestation, maternal (F0), embryonic (F1), and migrating primordial germ cell (F2)
genomes can be simultaneously exposed to environmental influences. Accumulating …

Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the
pulmonary parenchyma caused by excessive extracellular matrix deposition. Despite the …