Biomarkers of infection and sepsis

SM Opal, X Wittebole - Critical care clinics, 2020 - criticalcare.theclinics.com
Intensive care unit (ICU) practitioners and emergency department clinicians are in urgent
need of a major upgrade in their access to accurate and fast microbial diagnosis (Table 1) …

Early appropriate diagnostics and treatment of MDR Gram-negative infections

M Bassetti, SS Kanj, P Kiratisin… - JAC-Antimicrobial …, 2022 - academic.oup.com
The term difficult-to-treat resistance has been recently coined to identify Gram-negative
bacteria exhibiting resistance to all fluoroquinolones and all β-lactam categories, including …

N95 mask decontamination using standard hospital sterilization technologies

A Kumar, SB Kasloff, A Leung, T Cutts, JE Strong… - MedRxiv, 2020 - medrxiv.org
The response to the COVID-19 epidemic is generating severe shortages of personal
protective equipment around the world. In particular, the supply of N95 respirator masks has …

The role of diagnostics-driven antifungal stewardship in the management of invasive fungal infections: a systematic literature review

A Chakrabarti, N Mohamed… - Open forum …, 2022 - academic.oup.com
Antifungal stewardship (AFS) programs are key to optimizing antifungal use and improving
outcomes in patients with invasive fungal infections. Our systematic literature review …

Identifying the need for infection-related consultations in intensive care patients using machine learning models

LR Zwerwer, CF Luz, D Soudis, N Giudice… - Scientific Reports, 2024 - nature.com
Infection-related consultations on intensive care units (ICU) have a positive impact on quality
of care and clinical outcome. However, timing of these consultations is essential and to date …

Utility and applicability of rapid diagnostic testing in antimicrobial stewardship in the Asia-Pacific region: a Delphi consensus

A Apisarnthanarak, H Bin Kim… - Clinical Infectious …, 2022 - academic.oup.com
Rapid diagnostic tests (RDTs) facilitate fast and accurate identification of infectious disease
microorganisms and are a valuable component of multimodal antimicrobial stewardship …

State of the management of infections caused by multidrug-resistant Gram-negative organisms

A Yassin, M Huralska, JM Pogue, D Dixit… - Clinical Infectious …, 2023 - academic.oup.com
In the past decade, the prevalence of multidrug-resistant gram-negative (MDR-GN) bacterial
infections has increased significantly, leading to higher rates of morbidity and mortality …

Rationale for the development of a pentavalent meningococcal vaccine: a US-focused review

GS Marshall, J Fergie, J Presa, P Peyrani - Infectious Diseases and …, 2022 - Springer
While invasive meningococcal disease (IMD) is uncommon, it can result in serious sequelae
and even death. In 2018 in the United States, the incidence of IMD per 100,000 people was …

Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA

M Mizusawa, KC Carroll - Expert Review of Molecular Diagnostics, 2023 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent
cause of healthcare-and community-associated infections. Nasal carriage of MRSA is a risk …

Rapid diagnostic test value and implementation in antimicrobial stewardship across low-to-middle and high-income countries: a mixed-methods review

LSP Moore, MV Villegas, E Wenzler… - Infectious Diseases and …, 2023 - Springer
Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and
use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship …