[HTML][HTML] Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics
This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …
[HTML][HTML] Insights into human cerebral white matter maturation and degeneration across the adult lifespan
White matter (WM) microstructural properties change across the adult lifespan and with
neuronal diseases. Understanding microstructural changes due to aging is paramount to …
neuronal diseases. Understanding microstructural changes due to aging is paramount to …
[HTML][HTML] An atlas for human brain myelin content throughout the adult life span
AV Dvorak, T Swift-LaPointe, IM Vavasour, LE Lee… - Scientific reports, 2021 - nature.com
Myelin water imaging is a quantitative neuroimaging technique that provides the myelin
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …
[HTML][HTML] Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging
Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …
Hypertensive adults exhibit lower myelin content: a multicomponent relaxometry and diffusion magnetic resonance imaging study
BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
Structural and Functional Brain Correlates of Socioeconomic Status Across the Life Span: A Systematic Review
A Thanaraju, AA Marzuki, CJ Kei, WK Yung… - Neuroscience & …, 2024 - Elsevier
It is well-established that higher socioeconomic status (SES) is associated with improved
brain health. However, the effects of SES across different life stages on brain structure and …
brain health. However, the effects of SES across different life stages on brain structure and …
[HTML][HTML] C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …
neurite density and dispersion through computation of the neurite density index (NDI) and …
[HTML][HTML] Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging
JSR Alisch, N Khattar, RW Kim, LE Cortina… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS).
Previous work suggests that CBF differs between men and women, and declines with age …
Previous work suggests that CBF differs between men and women, and declines with age …
[HTML][HTML] Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study
The relationship between brain microstructure and aging has been the subject of intense
study, with diffusion MRI perhaps the most effective modality for elucidating these …
study, with diffusion MRI perhaps the most effective modality for elucidating these …
[HTML][HTML] The myelin water fraction serves as a marker for age-related myelin alterations in the cerebral white matter–a multiparametric MRI aging study
TD Faizy, C Thaler, G Broocks, F Flottmann… - Frontiers in …, 2020 - frontiersin.org
Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer
imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter …
imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter …