Glaucoma is defined by characteristic optic nerve damage and corresponding visual field
defects and is the leading cause of irreversible blindness in the world. Elevated intraocular …

Glaucoma is a clinically heterogeneous disease and the world's leading cause of
irreversible blindness. Therapeutic intervention can prevent blindness but relies on early …

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness
worldwide, disproportionately affects individuals of African ancestry. We conducted a …

Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …

Glaucoma is the leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common glaucoma subtype, is more prevalent and severe in …

Importance Primary open-angle glaucoma (POAG) is a highly heritable disease, with 127
identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful …

The success of genome-wide association studies (GWASs) in uncovering genetic variants
associated with complex eye diseases has paved the way for the development of risk …

Glaucoma is the leading cause of irreversible blindness worldwide. Currently the only
effective treatment for glaucoma is to reduce the intraocular pressure, which can halt the …

Purpose To assess the impact of genetic risk estimation for primary open-angle glaucoma
(POAG) in Japanese individuals. Design Cross-sectional analysis. Participants Genetic risk …

A major goal of precision medicine is to stratify patients based on their genetic risk for a
disease to inform future screening and intervention strategies. For conditions like primary …