Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all
current modalities of cancer therapy. A large set of genetic, functional and biochemical …

Growing evidence supports the importance of gut microbiota in the control of tumor growth
and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that …

Malaria remains one of the greatest public health challenges worldwide, particularly in sub-
Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum …

The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene
silencing mediated by either degradation or translation arrest of target RNA. This process is …

Melanoma is the cancer with the highest increase in incidence, and transformation of radial
growth to vertical growth (ie, noninvasive to invasive) melanoma is required for invasive …

Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

While amino acid restriction remains an attractive strategy for cancer therapy, metabolic
adaptations limit its effectiveness. Here we demonstrate a role of translational …