The characterization of mouse models of human disease is essential for understanding the
underlying pathophysiology and developing new therapeutics. Many diseases are often …

Familial fatal insomnia (FFI)—a hereditary prion disease caused by a mutation at codon 178
of the prion-protein (PrP) gene (PRNP) that leads to a D178N substitution in the protein …

Since animals express their internal state through behaviour, changes in said behaviour
may be used to detect early signs of problems, such as in animal health. Continuous …

Abstract Changes in pig behaviours are a useful aid in detecting early signs of compromised
health and welfare. In commercial settings, automatic detection of pig behaviours through …

Neurobehavioural analysis of mouse phenotypes requires the monitoring of mouse
behaviour over long periods of time. In this study, we describe a trainable computer vision …

Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …

Currently, no treatment can prevent the cognitive and motor decline associated with
widespread neurodegeneration in prion disease. However, we previously showed that …

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by
amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss …

Mammalian prions are the infectious agents responsible for transmissible spongiform
encephalopathies (TSE), a group of fatal, neurodegenerative diseases, affecting both …

Attention-deficit hyperactivity disorder (ADHD) is a neuropsychiatric syndrome, affecting
human infants and adolescents. Two main behavioural features are reported:(1) impaired …